OUR PROJECTS

Oligodendrocyte Biology

Oligodendrocyte Degeneration in Alzheimer’s Disease: Amyloid-Independent Effects of APOE Genotype on Cholesterol Metabolism

DNA repair and myelination

ATM Mutant Variants and Their Differential Effects on Myelin Pathology in Ataxia Telangiectasia – Revamping Genomic Diagnosis for Rare but Catastrophic Diseases
Is DNA Damage in Oligodendrocyte The Common Cause of Early Myelin Loss in The Aging Brain? – A Pilot Study (PI)

NeuroImaging

Identification of Novel Myelin-associated Targets for Early Detection of Age-related Neurological Disorder- from MRI to Target Molecules
Myelin Abnormalities as The Earliest Symptoms of Dementia – Harmonizing Neuroimaging and Cell Biology

Population genetics on myelination

TRIM47 in White Matter Hyperintensity – from the Population to the Cell
Bridging Integrator 1 (BIN1) in oligodendrocyte connects myelin degradations to age-related dementia

Digital Pathology

Flipping the glass slides - Virtualising histology education for medical laboratory scientists

PUBLICATIONS
Representative journal articles
1. Yeung SHS, Lee HSR, Cheng GWY, Ma IWT, Kofler J, Kent C, Ma F, Herrup K. Fornage M, Arai K, TSE KH* White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cell. The FASEB Journal 2024; 38:e70059. doi:10.1096/fj.202400689RR PMID: 39331575
2. Mok KKS, Yeung HS, Cheng GWY, MA IWT, Lee HSR, Herrup K, TSE KH* Apolipoprotein E ε4 disrupts oligodendrocytes differentiation in cholesterol deprivation by interference with lipid transport J Neurochem 2023 Apr;165(1):55-75 (Feature on Journal Cover) PMID: 36549843
3. Cheng GWY, Mok KKS, Yeung HS, Kofler J, Herrup K, TSE KH* Apolipoprotein E ε4 mediates myelin breakdown by targeting oligodendrocytes in sporadic Alzheimer’s disease J Neuropath Exp Neurol 2022 Aug 16;81(9):717-730 PMID: 35779013
4. Cheng A, TSE KH, Chow HM, Gan Y, Song X, Ma, Qian YX, She W, Karl Herrup ATM loss disrupts the autophagy-lysosomal pathway Autophagy 2020 Aug 14;1-13. doi: 10.1080/15548627.2020.1805860 PMID: 32757690

5. Huang H, van Zijl P, Han X, Don CM, Cheng GWY, TSE KH, Knutsson L, Chen L, Lai J, Wu E, Xu J, Chan KWY. Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose enhanced MRI. Science Advances 2020 May 13;6(20):eaba3884 PMID: 32426510

Full list of publications can be found in Pubmed