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Selected Publications

  1. Cheng GWY, Ma IWT, Huang J, Yeung SHS, Ho P, Chen Z, Mak HKH, Herrup K, Chang KWY, Tse KH* Cuprizone drives divergent neuropathological changes in different mouse models of Alzheimer's disease bioRxiv 2023 doi: https://doi.org/10.1101/2023.07.24.547147 PMID: 37546935 (Preprint)

  2. Law LH, Huang J, Xiao P, Liu Y, chen Z, Lai JHC, Han X, Cheng GWY, Tse KH, Chan KWY. Multiple CEST contrast imaging of nose-to-brain drug delivery using iohexol liposomes at 3T MRI. J Control Release. 2023 Feb; 354:208-220. PMID: 36623695  

  3. Mok KKS, Yeung HS, Cheng GWY, MA IWT, Lee HSR, Herrup K, TSE KH* Apolipoprotein E ε4 disrupts oligodendrocytes differentiation in cholesterol deprivation by interference with lipid transport   J. Neurochem. 2023 Apr;165(1):55-75 (Feature on Journal Cover) PMID: 36549843  

  4. Chen Z, Huang JP, Lai JHC, TSE KH, Xu J, Chan KWC. Chemical exchange saturation transfer (CEST) MRI detects myelin changes in cuprizone mouse model at 3T NMR in Biomedicine 2023 e4937 PMID: 36965064

  5. Cheng GWY, Mok KKS, Yeung HS, Kofler J, Herrup K, TSE KH*  Apolipoprotein E ε4 mediates myelin breakdown by targeting oligodendrocytes in sporadic Alzheimer’s disease   J. Neuropath. Exp. Neurol. 2022 Aug 16;81(9):717-730 PMID: 35779013

  6. TSE KH*, Cheng A, Yeung HS, Cheng WYG, Zhu B, Wang Q, Cui Y, Jiang L, Kofler J, Herrup K. Myelin pathology in ataxia-telangiectasia is the cell-intrinsic consequence of ATM deficiency in the oligodendrocytes medRxiv 2021.01.22.20245217; doi.org/10.1101/2021.01.22.20245217  (Preprint)

  7. Takase H, Hamanaka G, Ohtomo R, Ishikawa H, Chung K, Mandeville ET, Lok J, Fornage M, Herrup K, TSE KH, Lo E, Arai K. Transcriptome profiling of mouse corpus callosum after cerebral hypoperfusion Front. Cell Dev. Biol. 2021 Jun 17;9:685261  PMID: 34222254

  8. Cheng A, TSE KH, Chow HM, Gan Y, Song X, Ma, Qian YX, She W, Herrup K. ATM loss disrupts the autophagy-lysosomal pathway Autophagy 2021 14;1-13. doi: 10.1080/15548627.2020.1805860 PMID: 32757690  

  9. Huang H, van Zijl P, Han X, Don CM, Cheng GWY, TSE KH, Knutsson L, Chen L, Lai J, Wu E, Xu J, Chan KWY. Altered D-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose enhanced MRI. Sci. Adv. 2020 May 13;6(20):eaba3884 PMID: 32426510

  10. Sorond FA, Whitehead S, Arai K, Arnold D, Carmichael ST, De Carli C, Duering M, Fornage M, Flores-Obando RE, Graff-Radford J, Hamel E, Hess DC, Ihara M, Jensen MK, Markus HS, Montagne A, Rosenberg G, Shih AY, Smith EE, Thiel A, TSE KH, Wilcock D, Barone F. Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging. GeroScience. 2020 Feb;42(1):81-96. PMID: 31811528

  11. TSE KH*, Cheng A, Ma F, Herrup K DNA damage-associated oligodendrocyte degeneration precedes amyloid pathology and contributes to Alzheimer’s disease and dementia  Alzheimer Dement 2018 14(5):664-679  PMID: 29328926

  12. Cheng A, Zhao T, TSE KH, Chow HM, Cui Y, Jiang L, Du S, Herrup K. ATM and ATR play complementary roles in synaptic vesicle trafficking. Proc. Natl. Acad. Sci. U. S. A. 2018 115(2):E292-E301 PMID: 29279380

  13. Herrup K, TSE KH*, Chow HW, Loopholes in the DNA contract kill neurons. Nat Neurosci 2017 20(9):1192-1194. PMID: 28849789 (co-corresponding author, commentary)

  14. TSE KH*, Herrup K Re-imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead. J Neurochem 2017 143:432-444 PMID: 28547865 (Feature on Journal Cover; Top 20 most downloaded paper in the Journal, 2017-2018)

  15. TSE KH*, Herrup K. DNA damage in the oligodendrocyte lineage and its role in brain aging Mech. Ageing Dev. 2016 161(Pt A):37-50  PMID: 27235538

  16. TSE KH, Novikov LN, Wiberg M, Kingham PJ. Intrinsic mechanisms underlying the neurotrophic activity of adipose derived stem cells.  Exp Cell Res 2015 331:142-51  PMID: 25193075

  17. TSE KH, Chow KBS, WK Leung, Wong YH, Wise H. Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways. Neuroscience 2014. 267: 241-251. PMID: 24607321

 

Book Chapters

  1. TSE KH, Herrup K, and Trapp B, Chapter 65. Neurons and Neuroglia. Youmans and Winn Neurological Surgery. Volume 1; pp 468  8th edition, Elsevier, Philadelphia. 2022

 

*Corresponding Author/Co-Corresponding Author

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